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Pregnancy-induced hypertension(PIH),including gestational hypertension and preeclampsia,accounts for the majority of maternal and perinatal morbidity and mortality.Strontium(Sr)has been recently associated with preeclampsia in a small group of women;however,the role of Sr in PIH is not fully understood and warrants further investigation.In this study,we examined the association between urinary Sr levels and PIH,and assessed the effect of maternal age on the association.Urinary Sr concentrations were measured in 5423 pregnant women before delivery by inductively coupled plasma mass spectrometry(ICP-MS).Logistic regression analysis adjusting for potential confounders was applied to explore the association between Sr and PIH,and to evaluate the Sr-PIH relationship stratified by maternal age.Among the participants,200(3.83%)women were diagnosed with PIH.Compared with non-PIH women,women who developed PIH had lower urinary Sr concentrations(131.26 vs.174.98 pg/L creatinine,P<0.01).With the natural log-transformed urinary creatinine-standardized Sr concentrations increasing,the risk of PIH decreased significantly[adjusted OR=0.60(95%CI:0.51,0.72)].Furthermore,the significant association of Sr with PIH was found among women under 35 years(P<0.01).Our finding suggested that Sr may play a potential protective role in the pathogenesis of PIH,especially among young pregnant women under 35 years old.
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篇名 Association of Urinary Strontium Levels with Pregnancy-induced Hypertension
来源期刊 当代医学科学(英文) 学科
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年,卷(期) 2021,(3) 所属期刊栏目 ORIGINAL ARTICLES
研究方向 页码范围 535-541
页数 7页 分类号
字数 语种 英文
DOI 10.1007/s11596-021-2366-6
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华中科技大学学报(医学英德文版)
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1672-0733
42-1679/R
武汉市航空路13号同济医学院学报
eng
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