Discovery of Natural Co-occurring Enantiomers of Monoterpenoid Indole Alkaloids

• 作者: Yang Yu Mei-Fen Bao Xiang-Hai Cai
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: Concise Reports
• 页码范围: 866-872
• 页数: 7页
• 语种: 英文
• DOI: 10.1002/cjoc.202000574

摘要

Two new pairs of monoterpenoid indole alkaloids (MIAs) enantiomers as well as their new congeners were isolated from stems of Tabernaemontana bovina Lour.(Apocynaceae).Their structures were elucidated by spectroscopic analyses and confirmed by X-ray diffractions and computational calculations.Tabovine A,tabovine B and tabovines C—D possessed unprecedented 6/5/5/6/6,6/5/5/6/5 and 6/5/6/6/6 ring systems,respectively.It is the first time to report co-occurring enantiomers of MIAs.Additionally,the explanation concerning biogenesis of MIAs was provided.The findings would open a new window where we could disclose more di-verse MIAs.