Cracking the Codes of Cortical Glial Progenitors: Evidence for the Common Lineage of Astrocytes and Oligodendrocytes

• 作者: Hao Huang John L.Rubenstein Mengsheng Qiu
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: Editorial
• 页码范围: 437-439
• 页数: 3页
• 语种: 英文

摘要

During the development of the central nervous system (CNS), neuroepithelial cells in the ventricular zone are multipotent stem cells that can generate neurons and macroglia (astrocytes or oligodendrocytes).It is generally thought that these progenitor cells sequentially produce neurons followed by glia.The lineage relation between astrocytes and oligodendrocytes has long been under study, but remains controversial.In the 1980s, Martin Raff's group [1] described a glial progenitor cell, termed an O-2A cell, that can differentiate into astrocytes or oligodendrocytes in vitro, depending on the culture conditions.