Causal effect of education on type 2 diabetes:A network Mendelian randomization study

• 作者: Li-Zhen Liao Zhi-Chong Chen Wei-Dong Li Xiao-Dong Zhuang Xin-Xue Liao
• 来源期刊: 世界糖尿病杂志:英文版(电子版)
• 学科: 医学
• 关键词: Mendelian randomization EDUCATION Type 2 diabetes mellitus Genome-wide association study Coronary heart disease Body mass index
• 年，卷（期）: 2021,（3）
• 页码范围: 261-277
• 页数: 17页
• 分类号: R58

摘要

BACKGROUND The causality between education and type 2 diabetes(T2DM)remains unclear.AIM To identify the causality between education and T2DM and the potential metabolic risk factors[coronary heart disease(CHD),total cholesterol,lowdensity lipoprotein,triglycerides(TG),body mass index(BMI),waist circumference(WC),waist-to-hip ratio(WHR),fasting insulin,fasting glucose,and glycated hemoglobin]from summarized genome-wide association study(GWAS)data used a network Mendelian randomization(MR).METHODS Two-sample MR and network MR were performed to obtain the causality between education-T2DM,education-mediator,and mediator-T2DM.Summary statistics from the Social Science Genetic Association Consortium(discovery data)and Neale Lab consortium(replication data)were used for education and DIAGRAMplusMetabochip for T2DM.RESULTS The odds ratio for T2DM was 0.392(95%CI:0.263-0.583)per standard deviation increase(3.6 years)in education by the inverse variance weighted method,without heterogeneity or horizontal pleiotropy.Education was genetically associated with CHD,TG,BMI,WC,and WHR in the discovery phase,yet only the results for CHD,BMI,and WC were replicated in the replication data.Moreover,BMI was genetically associated with T2DM.CONCLUSION Short education was found to be associated with an increased T2DM risk.BMI might serve as a potential mediator between them.