Challenges and strategies in progress of drug delivery system for traditional Chinese medicine Salviae Miltiorrhizae Radix et Rhizoma(Danshen)

• 作者: Ruo-ning Wang Hua-cong Zhao Jian-yu Huang Hong-lan Wang Jun-song Li Yin Lu Liu-qing Di
• 来源期刊: 中草药（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Reviews
• 页码范围: 78-89
• 页数: 12页
• 语种: 英文

摘要

Traditional Chinese medicines(TCMs),with a history of thousands of years,are widely used clinically with effective treatment.However,the drug delivery systems(DDSs)for TCMs remains major challenges due to the characteristics of multi-components including alkaloids,flavones,anthraquinones,glycosides,proteins,volatile oils and other types.Therefore,the novel preparations and technology of modern phar-maceutics is introduced to improve TCM therapeutic effects due to instability and low bioavailability of active ingredients.Salviae Miltiorrhizae Radix et Rhizoma,the radix and rhizomes of Salvia miltiorrhiza Bunge(Danshen in Chinese),is a well known Chinese herbal medicine for protecting the cardiovascular system,with active ingredients mainly including lipophilic tanshinones and hydrophilic salvianolic acids.In this review,this drug is taken as an example to present challenges and strategies in progress of DDSs for TCMs.This review would also summary the characteristics of active ingredients in it including physic-ochemical properties and pharmacological effects.The purpose of this review is to provide inspirations and ideas for the DDSs designed from TCMs by summarizing the advances on DDSs for both single-and multi-component from Danshen.