EphA2:A promising therapeutic target in breast cancer

• 作者: Ping Zhao Dewei Jiang Yunchao Huang Ceshi Chen
• 来源期刊: 遗传学报
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: Review
• 页码范围: 261-267
• 页数: 7页
• 语种: 英文

摘要

Ephrin type-A receptor 2 (EphA2),a receptor tyrosine kinase,is overexpressed in human breast cancers often linked to poor patient prognosis.Accumulating evidence demonstrates that EphA2 plays important roles in several critical processes associated with malignant breast progression,such as proliferation,survival,migration,invasion,drug resistance,metastasis,and angiogenesis.As its inhibition through multiple approaches can inhibit the growth of breast cancer and restore drug sensitivity,EphA2 has become a promising therapeutic target for breast cancer treatment.Here,we summarize the expression,functions,mechanisms of action,and regulation of EphA2 in breast cancer.We also list the potential therapeutic strategies targeting EphA2.Furthermore,we discuss the future directions of studying EphA2 in breast cancer.