The molecular conformation of silk fibroin regulates osteogenic cell behavior by modulating the stability of the adsorbed protein-material interface

• 作者: Yanlin Long Xian Cheng John A.Jansen Sander G.C.Leeuwenburgh Jing Mao Fang Yang Lili Chen
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 188-199
• 页数: 12页
• 语种: 英文

摘要

INTRODUCTION Silk fibroin (SF), a natural protein derived from Bombyx mori silk cocoons, is a millennium-old material that has been recently widely adopted in biomedical engineering.1 SF exhibits attractive features for the production of bone-related biomaterials, such as robust mechanical properties,2 hypoallergenic features,3 vascular-ization,4 tunable biodegradation,5 the ability to accelerate biomineralization of collagen,6 and the ability to act as template for the growth of hydroxyapatite.7 Over the past decades, SF has been shown to be a promising polymer to construct various stiff materials to support bone formation. The application of stiff SF materials ranges from scaffolds1 to implants,2 membranes,7–8 and coatings.