Analysis of the medication rules of the national patent compound for the treatment of functional dyspepsia

• 作者: Shan-Shan Yang Xue-Zhi Zhang Hui Ye Shao-Dong Hao Xin Deng Hui-Xia Xiao
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Original article
• 页码范围: 52-58
• 页数: 7页
• 语种: 英文

摘要

Objective: Based on data mining software, applying frequent itemsets, association rules, hierarchical clustering, complex networks and other data mining methods to analyze the usage and compatibility of traditional Chinese medicine(TCM) patent compound for functional dyspepsia. Method: Use the Chinese patent database to search the compound for the treatment of functional dyspepsia, exclude traditional Chinese medicine extracts, single drugs, combined use of Chinese and Western medicines, etc., screen the patented compound of TCM, establish an Excel data table, and apply data mining software to The data is subjected to frequency statistics, association rules, cluster analysis and complex network analysis. Result: A total of 238 prescriptions for functional dyspepsia were screened. The four qi of the drugs were mainly warm and calm, the five flavors were mainly sweet and spicy, and the spleen and stomach were the main meridians. The top 10 Chinese medicines with higher frequency are Shanzha、Chenpi、Gancao、Maiya、Jineijin、Fuling、Baizhu、Shenqu、Houpo、Banxia; frequent itemsets show that the drugs are mainly compatible with qi and spleen, qi and digestion; association rules The analysis shows that the common drug pairs used in the treatment of functional dyspepsia include Chenpi-Shanzha、Maiya-Shanzha、Jineijin-Shanzha, etc.; cluster analysis found that there are 4 types of drugs for functional dyspepsia, mainly including drugs for regulating qi-flowing for harmonizing stomach, drugs for soothing liver and promoting Qi, drugs for eliminating food and resolving accumulation, drugs for benefiting qi and strengthening spleen; the 22-flavor Chinese medicine in the core drug network, the core compatibility is mainly to eliminate stagnation and spleen. Conclusion: Data mining research provides a reference for the clinical treatment of functional dyspepsia and the development of TCM formulas; Clinical treatment of functional dyspepsia should grasp the basic principles of strengthening vital energy and eliminating pathogenic factors to benefit qi, strengthen the spleen, and eliminate food. It is a basic treatment method, taking into account the methods of regulating qi-flowing for harmonizing stomach, soothing the liver and relieving depression, relieving dampness and dampness, and combining the specific conditions of patients with syndrome differentiation and treatment.