Effective treatment of SARS-CoV-2-infected rhesus macaques by attenuating inflammation

• 作者: Shuaiyao Lu Jingjing Zhao Jiebin Dong Hongqi Liu Yinhua Zhu Honggang Li Liping Liu Yun Yang Shicheng Sun Yifan Song Yuan Zhao Ruiping She Tuoping Luo Hongkui Deng Xiaozhong Peng
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: LETTERS TO THE EDITOR
• 页码范围: 229-232
• 页数: 4页
• 语种: 英文

摘要

Dear Editor, The COVID-19 pandemic caused by the SARS-CoV-2 virus has caused a significant public health crisis worldwide.Recent studies show that excessive inflammatory response is critical for SARS-CoV-2 pathogenesis and COVID-19 severity,1 which can lead to acute lung injury(ALI)and acute respiratory distress syndrome(ARDS).2 One major factor for acute inflammation in SARS-CoV-2 infection is the inflammatory macrophages,which has been considered important for the production of large amounts of proinflammatory cytokines.3 Autopsy identified an intense infiltra-tion of macrophages in the lung tissues of fatal COVID-19 patients.4 Furthermore,single-cell RNA sequencing(scRNA-seq)showed a higher proportion of macrophages presenting in bronchoalveolar lavage fluid(BALF)of severe COVID-19 patients.5 Consistent with studies of SARS-CoV-2,infiltration and accumula-tion of macrophages in the lung were also found in other coronavirus diseases.6 Depletion of macrophages protected mice from lethal SARS-CoV infection,highlighting the important roles of macrophages in coronavirus-induced symptoms.7 Therefore,targeting macrophages to regulate hyperinflammation in SARS-CoV-2 infection could be an effective strategy to treat COVID-19 patients.