Amid intensifying China-US competition and a global power shift accelerated by the novel coronavirus pandemic, combined with major ongoing transformations in the international landscape, the trajectory of the relationship between Russia and the United States has become critically significant, not only to China, but also to global strategic stability and the prospects for reform of the international order. What policy will the US under the Biden administration adopt toward Russia and how will the latter respond? Will Russia-US relations further deteriorate or witness a rebound? These questions and their potential influence on international politics demand our close attention.