Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea

• 作者: K.P.Swathi Saravanan Jayaram Deepa Sugumar Emdormi Rymbai
• 来源期刊: 中草药（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Original Articles
• 页码范围: 243-249
• 页数: 7页
• 语种: 英文

摘要

Objective:Clitoria ternatea is a well-known bioactive plant used to treat several inflammatory ailments in Ayurvedic system of medicine in India.The present investigation aimed to determine the anti-inflammatory and anti-arthritic activity of ethanolic extract of Clitoria ternatea roots (EECT) in animal models.Methods:The anti-inflammatory activity of the EECT was evaluated by carrageenan and histamine-induced paw edema,Results:EECT showed a significant reduction in mean paw edema volume in both carrageenan and histamine-induced inflammation.The efficacy of EECT in rheumatoid arthritis was tested against Freund's complete adjuvant (CFA) induced arthritic model in Wistar rats.The anti-arthritic effect of EECT was determined by systematic scoring of arthritis symptoms and measuring paw edema.A consid-erable decrease in paw diameter was observed in the EECT (200 and 400 mg/kg) and diclofenac (10 mg/kg) treated groups after day 7.Diclofenac (10 mg/kg) and EECT (400 mg/kg) showed a significant reduc-tion in paw diameter from day 14 compared with CFA control (P ＜ 0.001),The anti-arthritic activity was also confirmed from the altered biochemical,haematological (Hb,RBC and WBC) and anti-oxidant param-eters (SOD,MDA,CAT,and GSH).EECT (400 and 200 mg/kg) also showed a marked inhibition of joint destruction.Conclusion:This study provides a pharmacological rationale for the traditional use of C ternatea against inflammation and rheumatoid arthritis in India.