ANALYSIS OF THE GENOMIC DISTANCE BETWEEN BAT CORONAVIRUS RATG13 AND SARS-COV-2 REVEALS MULTIPLE ORIGINS OF COVID-19

• 作者: Shaojun PEI Stephen S.-T.YAU
• 来源期刊: 数学物理学报（英文版）
• 年，卷（期）: 2021,（3）
• 页码范围: 1017-1022
• 页数: 6页
• 语种: 英文
• DOI: 10.3969/j.issn.0252-9602.2021.03.023

摘要

The severe acute respiratory syndrome COVID-19 was discovered on Decem-ber 31,2019 in China.Subsequently,many COVID-19 cases were reported in many other countries.However,some positive COVID-19 samples had been reported earlier than those officially accepted by health authorities in other countries,such as France and Italy.Thus,it is of great importance to determine the place where SARS-CoV-2 was first transmitted to human.To this end,we analyze genomes of SARS-CoV-2 using k-mer natural vector method and compare the similarities of global SARS-CoV-2 genomes by a new natural metric.Be-cause it is commonly accepted that SARS-CoV-2 is originated from bat coronavirus RaTG13,we only need to determine which SARS-CoV-2 genome sequence has the closest distance to bat coronavirus RaTG13 under our natural metric.From our analysis,SARS-CoV-2 most likely has already existed in other countries such as France,India,Netherland,England and United States before the outbreak at Wuhan,China.