The coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 infection is a major threat to global public health. SARS-COV-2 not only activates the human immune system but also causes severe damage to multiple organs by binding to specific virus receptors[1].Basigin (BSG) is considered as the second important target for SARS-CoV-2 invasion after angiotensin converting enzyme 2 (ACE2)[2], which may mediate a variety of tissue damage, such as in the uterus[3] and brain[4].