Nucleic acids analysis

• 作者: Yongxi Zhao Xiaolei Zuo Qian Li Feng Chen Yan-Ru Chen Jinqi Deng Da Han Changlong Hao Fujian Huang Yanyi Huang Guoliang Ke Hua Kuang Fan Li Jiang Li Min Li Na Li Zhenyu Lin Dingbin Liu Juewen Liu Libing Liu Xiaoguo Liu Chunhua Lu Fang Luo Xiuhai Mao Jiashu Sun Bo Tang Fei Wang Jianbin Wang Lihua Wang Shu Wang Lingling Wu Zai-Sheng Wu Fan Xia Chuanlai Xu Yang Yang Bi-Feng Yuan Quan Yuan Chao Zhang Zhi Zhu Chaoyong Yang Xiao-Bing Zhang Huanghao Yang Weihong Tan Chunhai Fan
• 来源期刊: 中国科学：化学（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: INVITED REVIEWS
• 页码范围: 171-203
• 页数: 33页
• 语种: 英文

摘要

Nucleic acids are natural biopolymers of nucleotides that store,encode,transmit and express genetic information,which play central roles in diverse cellular events and diseases in living things.The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies,clinical diagnosis,environmental analysis,food safety and forensic analysis.During the past decades,the field of nucleic acids analysis has been rapidly advancing with many technological breakthroughs.In this review,we focus on the methods developed for analyzing nucleic acids,nucleic acids-based analysis,device for nucleic acids analysis,and applications of nucleic acids analysis.The representative strategies for the development of new nucleic acids analysis in this field are summarized,and key advantages and possible limitations are discussed.Finally,a brief perspective on existing challenges and further research development is provided.