Kidney injury molecule-1:a novel entry factor for SARS-CoV-2

• 作者: Cheng Wan Chun Zhang
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Highlight
• 页码范围: 159-160
• 页数: 2页
• 语种: 英文
• DOI: 10.1093/imcb/miab006

摘要

Renal involvement occurs frequently among patients with coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),and acute kidney injury(AKI)is associated with poor prognosis and mortality of COVID-19.The potential mechanisms of AKI include direct viru-lence of SARS-CoV-2 and indirect mecha-nisms such as hyperinflammation,hypercoagulation,and unspecific kidney injury factors(Gabarre et al.,2020).The existence of infective SARS-CoV-2 in kidney has been verified providing a definite evidence of renal tropism and di-rect invasion of SARS-CoV-2(Braun et al.,2020).Ascertaining the mechanism of SARS-CoV-2 entry will pave the way for preventing the infection and even tack-ling this epidemic.