Smart morphing wing, which is equipped with smart materials and able to change struc-tural geometry adaptively, can further improve aerodynamic efficiency of aircraft. This paper pre-sents a new integrated layout and topology optimization design for morphing wing driven by shape memory alloys (SMAs). By simultaneously optimizing the layout of smart actuators and topology of wing substrate, the ultimately determined configuration can achieve smooth, continuous and accurate geometric shape changes. In addition, aerodynamic analysis is carried out to compare smart morphing wing with traditional hinged airfoil. Finally, the optimized smart wing structure is constructed and tested to demonstrate and verify the morphing functionality. Application set-backs are also pointed out for further investigation.