Clinical observation of Yiqi Qingdu Prescription(益气清毒方)on the treatment of intermediate-stage and advanced non-small-cell lung cancer

• 作者: LIANG Qijun TANG Xiaoling YU Jiong XIONG Monian ZHU Huifang XIONG Linkai ZENG Ru YU Peiwen
• 来源期刊: 中医杂志（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Research Articles
• 页码范围: 308-315
• 页数: 8页
• 语种: 英文
• DOI: 10.19852/j.cnki.jtcm.2021.02.009

摘要

OBJECTIVE:To observe the effects of the Yiqi Qing-du prescription(益气清毒方)on intermedi-ate-stage and advanced non-small-cell lung cancer(NSCLC).METHODS:In total,300 patients with intermedi-ate-stage or advanced NSCLC were randomly and equally divided into three groups using comput-er-generated random numbers as follows:Western medicine(WM),Chinese medicine(CM),and inte-grated Traditional Chinese and Western Medicine(IM).After 3 months of treatment,the overall re-sponse rate(ORR);disease control rate(DCR);symp-tom score(SS);Karnofsky performance status(KPS);adverse event score;counts of CD3+,CD4+,and CD8+cells;CD4+/CD8+ratio;and carcinoembryonic antigen(CEA)level were compared among the groups.RESULTS:The ORRs were 30.36％,20.24％,and 7.87％in the IM,CM,and WM groups,respectively,whereas the DCRs were 85％,75％,and 73％,respec-tively.Compared to the CM group,the ORR was sig-nificantly higher in the WM and IM groups,whereas the DCR was significantly higher in the IM group(all P＜0.05).SS was obviously higher in the WM group than in the other two groups(both P＜0.01).KPS was significantly lower in the WM group after treatment(P=0.005).The mean number of adverse events was significantly lower in the CM(2.2±1.3)and IM(2.4±1.3)groups than in the WM group(4.6±1.7,both P＜0.05).CD3+cell counts were signifi-cantly decreased in the WM group(P=0.031).In the IM group,CD8+cell counts were increased after treatment,whereas the CD4+/CD8+ratio was de-creased(both P＜0.01).Compared with the WM group,CD3+(P=0.01),CD4+(P=0.044),and CD8+(P=0.009)cell counts were significantly higher in the IM group,whereas the CD4+/CD8+ratio was sig-nificantly lower(P=0.011).Relative to the CM group,CD8+cell counts were significantly higher(P=0.001)and the CD4+/CD8+ratio was significant-ly lower in the IM group(P=0.001).CEA levels were significantly increased in the CM group(P=0.023).CONCLUSION:The Yiqi Qingdu prescription can im-prove the outcomes of WM in patients with NSCLC.