Microbial production of L-malate from renewable non-food feedstocks

• 作者: Youming Jiang Xiaohan Ye Tianwen Zheng Weiliang Dong Fengxue Xin Jiangfeng Ma Min Jiang
• 来源期刊: 中国化学工程学报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Synthetic Biotechnology and Metabolic Engineering
• 页码范围: 105-111
• 页数: 7页
• 语种: 英文

摘要

L-malate is an intermediate of the tricarboxylic acid cycle which is naturally occurred in various microor-ganisms,and it has been widely applied in polymer,beverage and food,textile,agricultural and pharma-ceutical industries.Driven by the pursuit of a sustainable economy,microbial production of L-malate has received much attention in last decades.In this review,we focus on the utilization of wastes and/or by-products as feedstocks for the microbial production of L-malate.Firstly,we present the recent develop-ments on the natural or engineered metabolic pathways that dedicate to the biosynthesis of L-malate,and also provide a comprehensive discussions on developing high-efficient producers.Then,the recent achievements in microbial production of L-malate from various carbon sources were concluded and dis-cussed.Furthermore,some abundant non-food feedstocks which have been used for microbial produc-tion of other chemicals were reviewed,as they may be potential candidate feedstock for L-malate production in future.Finally,we outlined the major challenges and proposed further improvements for the production of L-malate.