Research progress on the correlation between cathepsin L and cardiovascular disease

• 作者: BI Tian-tian YAN Bo
• 来源期刊: 岭南心血管病杂志（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: ARTICLE REVIEW
• 页码范围: 210-214,封3
• 页数: 6页
• 语种: 英文

摘要

Background Cathepsin L (CTSL),a member of the cysteine protease cathepsin family,is an important Lyso-somal peptidase,which has the best activity in an acidic environment and less activity in a neutral environment.Its physiological function involves proteolysis,antigen presentation,T cell development,cell apoptosis,and em-bryonic development,and is closely related to the occurrence and development of various types of cancer,cardio-vascular disease,and kidney disease.In this paper,the role and mechanism of CTSL in the development of athero-sclerosis,coronary heart disease,restenosis,abdominal aortic aneurysm,and dilated cardiomyopathy were briefly reviewed.