A comparison between two definitions of contrast-induced acute kidney injury for risk of mortality in patients with anemia:A large cohort retrospective study with 5,406 patients

• 作者: YING Ming LU Hong-yu WANG Bo LUN Zhu-bin WEI Shui-sheng LIU Yong CHEN Zhu-jun
• 来源期刊: 岭南心血管病杂志（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: CLINICAL STUDIES
• 页码范围: 215-222,238
• 页数: 9页
• 语种: 英文

摘要

Background The relationship between contrast-induced acute kidney injury (CI-AKI) and long-term mortali-ty of anemia patients still remain controversial.Previous researches indicated that inconsistent definition may con-tributed to this problem.Methods This study conducted a retrospective cohort study enrolling 5,406 patients with anemia undergoing coronary angiography or percutaneous coronary intervention between January 2007 and December 2018 in Guangdong Provincial People's Hospital.The CI-AKI was evaluated according to two defini-tions:1.CI-AKIA:With a serum creatinine (SCr) elevation of 25％ or 0.5 mg/dL from baseline in the first 72 hours after procedure;2:CI-AKIB:With a SCr elevation of 50％ or 0.3 mg/dL from baseline in the first 72 hours after procedure.The endpoint was all-cause mortality.Univariable and multivariable Cox regression model were used to explore association between long-term all-cause mortality and CI-AKI.Population attributable risks(PARs) based on two different CI-AKI definitions for mortality were calculated.Results CI-AKIA was associat-ed with 1.36 fold risk of long-term death (HR:1.36,95％ CI:1.18-1.57),while CI-AKIB was associated with 1.32 fold risk of long-term death (HR:1.32,95％ CI:1.13-1.54).Between two definitions,the prevalence of CI-AKI was higher for CI-AKIA (16.7％),compared with CI-AKIB (12.6％).For the PARs,PAR based on CI-AKIA (PAR:5.65,95％ CI:2.91-8.67),was higher than that based on CI-AKIB (PAR:3.87,95％ CI:1.61-6.36).Conclusions Patients complicated with CI-AKI had a higher risk of mortality than those without CI-AKI in all definitions.The prevalence and PAR of CI-AKI were higher when it was defined as CI-AKIA.CI-AKIA was considered as a better definition to identify anemia patients with higher risk of CI-AKI and higher risk of CI-AKI-associated mortality.