Regulation of nonsense-mediated mRNA decay in neural development and disease

• 作者: Paul Jongseo Lee Suzhou Yang Yu Sun Junjie U.Guo
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: Reviews
• 页码范围: 269-281
• 页数: 13页
• 语种: 英文
• DOI: 10.1093/jmcb/mjab022

摘要

Eukaryotes have evolved a variety of mRNA surveillance mechanisms to detect and degrade aberrant mRNAs with potential delete-rious outcomes.Among them,nonsense-mediated mRNA decay (NMD) functions not only as a quality control mechanism target-ing aberrant mRNAs containing a premature termination codon but also as a posttranscriptional gene regulation mechanism tar-geting numerous physiological mRNAs.Despite its well-characterized molecular basis,the regulatory scope and biological functions of NMD at an organismal level are incompletely understood.In humans,mutations in genes encoding core NMD factors cause specific developmental and neurological syndromes,suggesting a critical role of NMD in the central nervous system.Here,we review the accumulating biochemical and genetic evidence on the developmental regulation and physiological functions of NMD as well as an emerging role of NMD dysregulation in neurodegenerative diseases.