CytoBrain:Cervical Cancer Screening System Based on Deep Learning Technology

• 作者: Hua Chen Juan Liu Qing-Man Wen Zhi-Qun Zuo Jia-Sheng Liu Jing Feng Bao-Chuan Pang Di Xiao
• 来源期刊: 计算机科学技术学报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Special Section on AI Big Data Analytics in Biology and Medicine
• 页码范围: 347-360
• 页数: 14页
• 语种: 英文

摘要

Identification of abnormal cervical cells is a significant problem in computer-aided diagnosis of cervical cancer.In this study,we develop an artificial intelligence (AI) system,named CytoBrain,to automatically screen abnormal cervical cells to help facilitate the subsequent clinical diagnosis of the subjects.The system consists of three main modules:1) the cervical cell segmentation module which is responsible for efficiently extracting cell images in a whole slide image (WSI);2) the cell classification module based on a compact visual geometry group (VGG) network called CompactVGG which is the key part of the system and is used for building the cell classifier;3) the visualized human-aided diagnosis module which can automatically diagnose a WSI based on the classification results of cells in it,and provide two visual display modes for users to review and modify.For model construction and validation,we have developed a dataset containing 198952 cervical cell images (60238 positive,25001 negative,and 113713 junk) from samples of 2312 adult women.Since CompactVGG is the key part of CytoBrain,we conduct comparison experiments to evaluate its time and classification performance on our developed dataset and two public datasets separately.The comparison results with VGG11,the most efficient one in the family of VGG networks,show that CompactVGG takes less time for either model training or sample testing.Compared with three sophisticated deep learning models,CompactVGG consistently achieves the best classification performance.The results illustrate that the system based on CompactVGG is efficient and effective and can support for large-scale cervical cancer screening.