Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains

• 作者: Jianye Xia Guan Wang Meng Fan Min Chen Zeyu Wang Yingping Zhuang
• 来源期刊: 中国化学工程学报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Biocatalysis and Bioreactor Engineering
• 页码范围: 178-184
• 页数: 7页
• 语种: 英文

摘要

The production capability of a fermentation process is predominately determined by individual strains,which ultimately affected ultimately by interactions between the scale-dependent flow field developed within bioreactors and the physiological response of these strains.Interpreting these complicated inter-actions is key for better understanding the scale-up of the fermentation process.We review these two aspects and address progress in strategies for scaling up fermentation processes.A perspective on how to incorporate the multiomics big data into the scale-up strategy is presented to improve the design and operation of industrial fermentation processes.