The Mechanism of the combination of radix paeoniae rubra-cortex moutan in treating cerebral hemorrhage based on network pharmacology

• 作者: Jia-Qi Chen Ge-Sheng Wang Yu-Jia Zhou Jia-Lin Liu Guang-Rong Song Zhen-Zhen Pei Can Zheng
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Original article
• 页码范围: 51-57
• 页数: 7页
• 语种: 英文

摘要

Objective:To clarify the material basis of Chinese medicine pair "Radix Paeoniae Rubra-Cortex Moutan"(Chishao-Mudanpi)and explore their mechanism in the treatment of ICH with network pharmacology. Methods:The active ingredients contained in Radix Paeoniae Rubra and Cortex Moutan were searched and selected based on the oral bioavailability prediction and drug-likeness prediction from the TCMSP database. Then the targets of cerebral hemorrhage were collected from GeneCards, OMIM, and DrugBank databases. After obtained the intersections of drugs and disease, the active component target disease interactive network diagram was drawn by Cytoscape software. The obtained key targets were uploaded to the STRING database for analysis and construct a PPI network map. GO function enrichment analysis and KEGG analysis were performed on the key target proteins. Results:Collected the active ingredients of Radix Paeoniae 119, Radix Paeoniae 55, including paeoniflorin, baicalin, β-sitosterol, etc. Related drug target protein 1190, ICH disease-related genes 823, " Radix Paeoniae - Radix Paeoniae " and 72 common targets of ICH, mainly acting on Akt1, IL6, VEGFA, CASP3, EGF, involving 133 related signaling pathways such as AGE-RAGE, TNF, IL-17, HIF1, PI3K-Akt. Conclusion:The combination of " Radix Paeoniae Rubra-Cortex Moutan " in the treatment of ICH has the characteristics of multiple pathways and multiple targets, which provides a reference and basis for further molecular biology verification in the future.