Current Understanding toward Isonitrile Group Biosynthesis and Mechanism

• 作者: Tzu-Yu Chen Jinfeng Chen Yijie Tang Jiahai Zhou Yisong Guo Wei-chen Chang
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Critical Review
• 页码范围: 463-472
• 页数: 10页
• 语种: 英文
• DOI: 10.1002/cjoc.202000448

摘要

Isonitrile group has been identified in many natural products.Due to the broad reactivity of N=C triple bond,these natural products have valuable pharmaceutical potentials.This review summarizes the current biosynthetic pathways and the corresponding enzymes that are responsible for isonitrile-containing natural product generation.Based on the strategies utilized,two fundamentally distinctive approaches are discussed.In addition,recent progress in elucidating isonitrile group formation mechanisms is also presented.