Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration

• 作者: Mei Wan Elise F.Gray-Gaillard Jennifer H.Elisseeff
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: REVIEWS
• 页码范围: 444-455
• 页数: 12页
• 语种: 英文

摘要

INTRODUCTION The musculoskeletal system (MSK), including bone, cartilaginous tissues, skeletal muscle, tendon, ligament, intervertebral disc, and others, is the structural framework for the body and enables movement. Bones are held in position by ligaments. Skeletal muscles power the movement of bones. Muscles and bones are connected through tendons. These tissues together form the articulating joints. In addition to providing physical support, MSK tissues have endocrine functions and communicate with other tissues to affect organism homeostasis and overall physiological health.