Roles of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues

• 作者: Lei Qin Tailin He Sheng Chen Dazhi Yang Weihong Yi Huiling Cao Guozhi Xiao
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: REVIEWS
• 页码范围: 456-472
• 页数: 17页
• 语种: 英文

摘要

INTRODUCTION Mechanotransduction is a fundamental ability that allows living organisms to receive and respond to physical signals from the internal and external environment and has been found and characterized in all five kingdoms of life. For bacteria or other simple organisms, mechanotransduction is required to sense stretching, osmotic pressure, and other mechanical forces.1 In mammals, mechanotransduction is involved in many physiological processes,2–3 such as touch, gravity, proprioception, sound, air flow, vascular development, and blood pressure. Successful and precise mechanotransduction is essential for proper organ function, whereas abnormal or faulty mechanotransduction could lead to a wide array of diseases, such as deafness,4 cardiovascular diseases,5 metabolic defects,3 fibrosis,2 cancer metastasis,6 neuro-nal disorders,7 and osteoporosis.