Optimal dual antiplatelet therapy strategy in elderly patients with acute coronary syndrome

• 作者: Monica Verdoia Rocco Gioscia Giuseppe De Luca
• 来源期刊: 老年心脏病学杂志（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: REVIEW
• 页码范围: 210-218
• 页数: 9页
• 语种: 英文

摘要

One out of three hospitalizations for acute coronary syndrome(ACS)involve nowadays elderly patients,carry-ing together a significant burden of comorbidities and a higher risk of complications.In particular,both ischemic and haemor-rhagic risk are markedly enhanced in advanced age,and strictly interconnected,challenging the management of dual antiplatelet therapy(DAPT)in these patients.The recent development of several therapeutic options in terms of duration and combination of antiplatelet agents have offered a wider spectrum of opportunities for a more individualized approach in the management of DAPT after an ACS,although the criteria for the selection of the most appropriate strategy in each patient still lack validation.In particular,dose-adjustment,early aspirin discontinuation,laboratory-driven tailoring and shorter or extended DAPT have been addressed with promising safety and efficacy results.The present review provides an updated overview on the emerging evid-encefrom randomized clinical trials and subanalyses dedicated to the management of DAPT in elderly patients presenting with ACS.