Donor Preactivation-Based Glycosylation: An Efficient Strategy for Glycan Synthesis

• 作者: Xianjin Qin Xin-Shan Ye
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Chemistry Authors Up Close
• 页码范围: 531-542
• 页数: 12页
• 语种: 英文
• DOI: 10.1002/cjoc.202000484

摘要

Carbohydrates have gained a lot of appreciation in the past few decades due to their important roles in numerous biological events.Acquiring a structurally well-defined carbohydrate compound is essential for the understanding of its functions.Although some innovative methods have been developed for the synthesis of complex oligosaccharides,glycan synthesis is in general still a time-consuming and difficult work.Herein,we will introduce the preactivation-based glycosylation strategy,which is an efficient protocol independent of the reactivity of glycosyl donor.This review will focus on summarizing the versatile applications of preactivation strategy in stereoselective glycosylation and one-pot assembly of biologically important oligosaccharides and even polysaccharides.