Overexpression of Lrp5 enhanced the anti-breast cancer effects of osteocytes in bone

• 作者: Shengzhi Liu Di Wu Xun Sun Yao Fan Rongrong Zha Aydin Jalali Yan Feng Kexin Li Tomohiko Sano Nicole Vike Fangjia Li Joseph Rispoli Akihiro Sudo Jing Liu Alexander Robling Harikrishna Nakshatri Bai-Yan Li Hiroki Yokota
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 494-506
• 页数: 13页
• 语种: 英文

摘要

INTRODUCTION Primary bone cancer is relatively rare, but bone is a frequent site of cancer metastases.1–2 Estrogen receptor (ER)-positive cancers preferentially metastasize to bone,3 but bone is also a common site of metastasis of ER-negative breast cancers, including triple-negative breast cancer.4 Many potential reasons for the high rate of bone metastasis, including chemotaxis mediated by cytokines, chemokines, and TGFβ-rich calcified matrix as a metastatic environment, have been considered.5 However, the role of osteocytes, which are the most abundant type of bone cells, in this process remains poorly understood.6 Focusing on the role of Wnt signaling, which is required for load-driven bone home-ostasis, we evaluated the interactions of tumor cells with mechanosensitive osteocytes.