Long-term Therapeutic Outcome and Prognostic Factors of Patients with Nasopharyngeal Carcinoma Receiving Intensity-modulated Radiotherapy:An Analysis of 608 Patients from Low-endemic Regions of China

• 作者: Jing HUANG Zhi-yong YANG Bian WU Qian DING You QIN Zhan-jie ZHANG Zhong-yuan YIN Zhi-wen LIANG Jun HAN Ye WANG Zhen-jun PENG Gang PENG Qin LI Gang WU Kun-yu YANG
• 来源期刊: 当代医学科学（英文）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 737-745
• 页数: 9页
• 语种: 英文
• DOI: 10.1007/s11596-021-2405-3

摘要

Objective:To evaluate the long-term outcome and prognostic factors of patients with nasopharyngeal carcinoma(NPC)from low-endemic regions of China who received definitive intensity-modulated radiation therapy(IMRT).Methods:The clinical data from 608 patients with newly-diagnosed non-metastatic NPC who have received initial treatment at our cancer center from January,2008 to December,2013 were retrospectively reviewed.All patients received definitive IMRT,and 87.7％ received platinum-based chemotherapy.Results:The median follow-up duration was 51 months(follow-up rate,98.5％;range,10-106 months)for the entire cohort.The 5-year overall survival rate was 79.7％.The 5-year local relapse-free survival rate,regional relapse-free survival rate,distant metastasis-free survival rate and progression-free survival rate were 92.4％,93.3％,79.2％and 74.3％,respectively.A total of 153 patients had experienced treatment failure,with distant metastasis as the primary cause in 77.1％(118/153).Patients with T4 or N3 diseases had a significantly poorer prognosis than other subcategories.Stage T4 and N3 were closely associated with distant metastasis,with the metastatic rate of 29.3％ and 45.5％,respectively.Conclusion:IMRT provides patients with non-metastatic NPC with satisfactory long-term survival.Both T stage and N stage are important prognostic factors for NPC patients.Patients with T4 or N3 diseases have significantly increased distant metastatic rates and poor survival time.