Apoptotic mechanism of premature ovarian failure and rescue ef-fect of Traditional Chinese Medicine:a review

• 作者: CAI Liang ZONG Daokuan TONG Guoqing LI Li
• 来源期刊: 中医杂志（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Review
• 页码范围: 491-498
• 页数: 8页
• 语种: 英文
• DOI: 10.19852/j.cnki.jtcm.2021.03.017

摘要

Social and environmental factors render premature ovarian failure(POF)as a major cause of decline or loss of female fertility.The natural pregnancy rate of patients with POF is only 5％-10％.Follicular atre-sia is the main factor in the pathogenesis of POF.Due to the unique ovarian physiological environ-ment and follicular developmental processes,the apoptosis of ovarian granulosa cells and oocytes to-gether cause follicular atresia,which involves the apoptosis-related internal and external pathways.Furthermore,during POF,apoptosis and oxidative stress forms a"vicious circle",which involves a vari-ety of changes between the molecules.The exist-ing pharmaceutical preparations such as gonadal hormones are the basic methods for the treatment of POF,and the curative effect was affirmative;how-ever,it was ineffective after withdrawn,while the long-term application led to adverse reactions.Tra-ditional Chinese Medicine(TCM)has a history of treating gynecological diseases and infertility and has gained increasing attention.Studies have shown that compounds isolated from herbal medi-cine exerted a positive effect on follicular atresia caused by cell apoptosis that also improved the POF.The present study reviewed the mechanisms underlying the apoptosis in POF and elaborated the internal mechanism of TCM in the treatment of the condition.