Exposure to PM2.5 Enhances the PI3K/AKT Signaling and Malignancy of ERα Expression-dependent Non-small Cell Lung Carcinoma

• 来源期刊: 生物医学与环境科学（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 319-323,中插9
• 页数: 6页
• 语种: 英文
• DOI: 10.3967/bes2021.041

摘要

Atmospheric particulate matter (PM) 2.5 is a major carcinogen?and?is?associated?with?an?increased risk of developing various cancers and pulmonary fibrous diseases[1–2]. Non-small cell lung cancer (NSCLC) is the major type of lung cancer with high morbidity and mortality rates. Epidemiological studies report that the incidence of NSCLC, particularly adenocarcinoma, significantly differs with the gender[3]. Female patients with NSCLC have unique epidemiologic characteristics, imaging profiles, clinical manifestations, and pathological characteristics[4]. Non-smoking women have a 2.5-times higher risk of developing NSCLC than non-smoking men, suggesting the effect of estrogen and its receptors[5–6]. Activated estrogen receptors (ERs) can regulate the expression of many genes and interact with several signaling pathways to regulate the malignancy of cancers;?however, the ER-related mechanism underlying the regulation of PM2.5-modulated?malignancy?of?NSCLC?is?unclear.