Structure of intact human MCU supercomplex with the auxiliary MICU subunits

• 作者: Wei Zhuo Heng Zhou Runyu Guo Jingbo Yi Laixing Zhang Lei Yu Yinqiang Sui Wenwen Zeng Peiyi Wang Maojun Yang
• 来源期刊: 蛋白质与细胞
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: LETTERS
• 页码范围: 220-229
• 页数: 10页
• 语种: 英文

摘要

Dear Editor, Mitochondrial Ca2+ homeostasis regulates energy production, cell division, and cell death.The basic properties of mitochondrial Ca2+ uptake have been firmly established.The Ca2+ influx is mediated by MCU, driven by membrane potential and using a uniporter mechanism (Vasington and Murphy, 1962).Patch-clamp analysis of MCU currents demonstrated that MCU is a channel with exceptionally high Ca2+ selectivity (Kirichok et al., 2004).