Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection

• 作者: Congshan Jiang Xiaowei Li Changrong Ge Yuanyuan Ding Tao Zhang Shuai Cao Liesu Meng Shemin Lu
• 来源期刊: 药物分析学报（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Review Papers
• 页码范围: 257-264
• 页数: 8页
• 语种: 英文

摘要

Coronavirus disease 2019 (COVID-19) has been a pandemic for more than a year.With the expanding second wave of the pandemic in winter,the continuous evolution of SARS-CoV-2 has brought new issues,including the significance of virus mutations in infection and the detection of asymptomatic infection.In this review,we first introduced several major SARS-CoV-2 mutations since the COVID-19 outbreak and then mentioned the widely used molecular detection techniques to diagnose COVID-19,primarily focusing on their strengths and limitations.We further discussed the effects of viral genetic variation and asymptomatic infection on the molecular detection of SARS-CoV-2 infection.The review finally sum-marized useful insights into the molecular diagnosis of COVID-19 under the special situation being challenged by virus mutation and asymptomatic infection.