Iron Catalyzed Isomerization of α-Alkyl Styrenes to Access Trisubstituted Alkenes

• 作者: Songgen Xu Guixia Liu Zheng Huang
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Concise Reports
• 页码范围: 585-589
• 页数: 5页
• 语种: 英文
• DOI: 10.1002/cjoc.202000492

摘要

Stereoselective isomerization of α-alkyl styrenes is accomplished using a new iron catalyst supported by phosphine-pyridine-oxazoline (PPO) ligand.The protocol provides an atom-efficient and operationally simple approach to trisubstituted alkenes in high yields with excellent regio-and stereoselectivities under mild conditions.The results of deuterium-labelling and radical trap experiments are consistent with an iron-hydride pathway involving reversible alkene insertion and β-H elimination.