Exudative hemorrhagic retinopathy related to all-trans retinoic acid differentiation syndrome in a patient with acute promyelocytic leukemia

• 作者: Emily KTam Steven Ness Crandall EPeeler
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: HEMORRHAGIC ACUTE CHEMOTHERAPY
• 年，卷（期）: 2021,（2）
• 页码范围: 323-325
• 页数: 3页
• 分类号: R73

摘要

Dear Editor,We report a case of significant exudative hemorrhagic retinopathy attributed to differentiation syndrome(DS).DS is a systemic inflammatory condition seen in patients with acute promyelocytic leukemia(APML)undergoing treatment with all-trans retinoic acid(ATRA).DS can lead to endothelial injury and capillary leakage throughout the body.Treatment with corticosteroids during chemotherapy has been shown to reduce the risk of developing DS[1-2].There are limited reports of the ocular manifestations of DS in the literature,including pale yellow choroidal lesions,scattered retinal hemorrhages,and serous retinal detachments[3-5].