Fe-Catalyzed Pictet-Spengler-Type Cyclization via Selective Four-Electron Reductive Functionalization of CO2

• 作者: Wen-Duo Li Jie Chen Dao-Yong Zhu Ji-Bao Xia
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Concise Reports
• 页码范围: 614-620
• 页数: 7页
• 语种: 英文
• DOI: 10.1002/cjoc.202000521

摘要

Herein,we describe a novel catalytic Pictet-Spengler-type cyclization using CO2 as a nontoxic and sustainable C1 feedstock with environmentally benign and non-precious-metal iron as catalyst.The reaction is achieved by selective four-electron reduction of CO2 into methylene level intermediate through carefully tuning the reaction parameters.A variety of tetrahydro-β-carbolines and other nitrogen-containing heterocycles can be easily obtained under mild conditions.Mechanistic studies have shown that tetrahydro-β-carbolines are probably obtained via spiroindolenine intermediates.