Three-dimensional cytoplasmic calcium propagation with boundaries

• 来源期刊: 理论物理通讯（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: STATISTICAL PHYSICS,SOFT MATTER AND BIOPHYSICS
• 页码范围: 87-98
• 页数: 12页
• 语种: 英文

摘要

Ca2+plays an important role in cell signal transduction.Its intracellular propagation is the most basic process of Ca2+signaling,such as calcium wave and double messenger system.In this work,with both numerical simulation and mean field ansatz,the three-dimensional probability distribution of Ca2+,which is read out by phosphorylation,is studied in two scenarios with boundaries.The coverage of distribution of Ca2+is found at an order of magnitude of μm,which is consistent with experimental observed calcium spike and wave.Our results suggest that the double messenger system may occur in the ER-PM junction to acquire great efficiency.The buffer effect of kinase is also discussed by calculating the average position of phosphorylations and free Ca2+.The results are helpful to understand the mechanism of Ca2+signaling.