The potential of ionic liquids in biopharmaceutical engineering

• 作者: Xuan Lin Zhiguo Su Yanli Yang Songping Zhang
• 来源期刊: 中国化学工程学报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Biomedical Engineering
• 页码范围: 236-243
• 页数: 8页
• 语种: 英文

摘要

Biopharmaceuticals,such as proteins,peptides,nucleic acids and vaccines,bring about great hopes for the prevention and treatment of various diseases,but the industrialization of these products still faces challenges such as structural instability,inefficient bioactivity and low bioavailability.Ionic liquids(ILs),the marvelous solvent media with inimitable and tunable properties,may provide alternative solu-tions to overcome the above problems of biopharmaceutical industry.Progress has gradually been made through studies by combination of ILs with biomacromolecules.The applications involved the stabiliza-tion,protection,and delivery of biopharmaceuticals.Recent trends are being forwarded to using ILs in vaccines and nucleic acid drugs.However,challenges remain on the toxicity and safety issues.Besides,the cost of adding ILs to the benefits of biopharmaceuticals need to be considered.