Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXeneswith Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection

• 作者: Yusi Peng Chenglong Lin Li Long Tanemura Masaki Mao Tang Lili Yang Jianjun Liu Zhengren Huang Zhiyuan Li Xiaoying Luo John R.Lombardi Yong Yang
• 来源期刊: 纳微快报（英文）
• 年，卷（期）: 2021,（3）
• 页码范围: 177-193
• 页数: 17页
• 语种: 英文

摘要

which is beneficial to achieve real-time monitoring and early warning of novel coronavirus. This research not only provides helpful theoretical guidance for exploring other novel SERS-active semiconductor-based materials but also provides a potential candidate for the practical applications of SERS technology. ABSTRACT The outbreak of coronavirus disease 2019 has seriously threatened human health. Rapidly and sensitively detecting SARS-CoV-2 viruses can help control the spread of viruses. However, it is an arduous challenge to apply semiconductor-based substrates for virus SERS detection due to their poor sensitivity. Therefore, it is worthwhile to search novel semiconductor-based substrates with excellent SERS sensitivity. Herein we report, for the first time, Nb2C and Ta2C MXenes exhibit a remarkable SERS enhancement, which is synergistically ena-bled by the charge transfer resonance enhancement and electromag-netic enhancement. Their SERS sensitivity is optimized to 3.0 × 106 and 1.4 × 106 under the optimal resonance excitation wavelength of 532 nm. Additionally, remarkable SERS sensitivity endows Ta2C MXenes with capability to sensitively detect and accurately identify the SARS-CoV-2 spike protein. Moreover, its detection limit is as low as 5 × 10-9 M,