Review of biosensing with whispering-gallery mode lasers

• 作者: Nikita Toropov Gema Cabello Mariana P.Serrano Rithvik R.Gutha Matías Rafti Frank Vollmer
• 来源期刊: 光：科学与应用（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Reviews
• 页码范围: 352-370
• 页数: 19页
• 语种: 英文

摘要

Lasers are the pillars of modern optics and sensing. Microlasers based on whispering-gallery modes (WGMs) areminiature in size and have excellent lasing characteristics suitable for biosensing. WGM lasers have been used for label-free detection of single virus particles, detection of molecular electrostatic changes at biointerfaces, and barcode-type live-cell tagging and tracking. The most recent advances in biosensing with WGM microlasers are described in this review. We cover the basic concepts of WGM resonators, the integration of gain media into various active WGM sensors and devices, and the cutting-edge advances in photonic devices for micro-and nanoprobing of biological samples that can be integrated with WGM lasers.