Testosterone,cardiomyopathies,and heart failure:a narrative review

• 作者: Rodica Diaconu Ionut Donoiu Oana Mirea Tudor Adrian Bǎl?eanu
• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: REVIEW
• 页码范围: 348-356
• 页数: 9页
• 语种: 英文
• DOI: 10.4103/aja.aja_80_20

摘要

Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomic pathways.It produces several changes in cardiomyocytes,the main actor of cardiomyopathies,which are characterized by pathological remodeling,eventually leading to heart failure.Testosterone is involved in contractility,in the energy metabolism of myocardial cells,apoptosis,and the remodeling process.In myocarditis,testosterone directly promotes the type of inflammation that leads to fibrosis,and influences viremia with virus localization.At the same time,testosterone exerts cardioprotective effects that have been observed in different studies.There is increasing evidence that low endogenous levels of testosterone have a negative impact in some cardiomyopathies and a protective impact in others.This review focuses on the interrelationships between testosterone and cardiomyopathies and heart failure.