Magnetic Ganoderma Lucidum Spores(mGLS):A Novel Regulatable Targeted Drug Delivery System

• 作者: Bin Han Zhankun Weng Yuhan Wu Xin Zhao Jingmei Li Qinhan Zhang Kaige Qu Bojian Liang Fenguo Zhou Guixia Liu Zuobin Wang
• 来源期刊: 仿生工程学报（英文版）
• 年，卷（期）: 2021,（4）
• 页码范围: 915-926
• 页数: 12页
• 语种: 英文
• DOI: 10.1007/s42235-021-0059-2

摘要

In the past decades,many materials have been studied as carriers for targeted drug delivery.However,there is a need for utilizable and selective carrier materials with few side effects.Here,the magnetic Ganoderma Lucidum Spores(mGLS)as a highly efficient targeted drug delivery carrier were explored.Then the regulatable targeted drug delivery system was verified by loading and releasing of the 5-Fluorouracil(5-FU).The results showed that the maximum of the loaded 5-FU reached 250.23 mg·g-1 in the mGLS.The cumulative release of the 5-FU for the drug delivery system could reach 80.11％and 67.14％in the PBS and HC1 after 48 h,respectively.In addition,this system showed the good pharmacokinetic properties in vivo.After 12 h,the blood concentration in the 5-FU@mGLS group kept at 5.3μg·mL-1 and was four times higher than that in the 5-FU group.In summary,the GLS as a natural microscale core-shell structures appears the striking application in carrier material for oral drug delivery.