Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters

• 作者: Ximin Chi Xiaorong Li Yun Chen Yuanyuan Zhang Qiang Su Qiang Zhou
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: LETTERS TO THE EDITOR
• 页码范围: 482-484
• 页数: 3页
• 语种: 英文

摘要

Dear Editor, The electroneutral K+-Cl-cotransporters(KCCs)play fundamental roles in trans-epithelial transport,cell volume regulation,and neuronal excitability.1 The neuronal-specific KCC2(SLC12A5)and glial-expressed KCC3(SLC12A6)are essential for normal develop-ment and function of the nervous system.Mutations in KCC2 have been linked with human idiopathic generalized epilepsy2 and schizophrenia.3 KCC3-dependent Cl-transport across the choroid plexus epithelia is involved in the production of cerebrospinal fluid.