Role of PAI-1 in adipose tissue senescence and inflammation in obesity

• 作者: XU Jin GAO Qian WU Jian-bo
• 来源期刊: 西南医科大学学报
• 年，卷（期）: 2021,（5）
• 页码范围: 439-444
• 页数: 6页
• 语种: 中文
• DOI: 10.3969/j.issn.2096-3351.2021.05.004

摘要

Plasminogen activator inhibitor-1 (PAI-1) is a member of the evolutionarily conserved serine pro-tease inhibitor family. The increased expression of PAI-1 leads to pathological diseases such as vascular diseases, obesity, and metabolic syndrome. Senescence-associated secretory phenotype (SASP) mediates tissue damage and plays a role in adipose tissue dysfunction. Chronic inflammation in adipose tissue is associated with the development of metabolic diseases, including obesity, insulin resistance, and type 2 diabetes. PAI-1 plays a vital role in adipose tissue physiology, glucose metabolism, insulin secretion and sensitivity, inflammation, and macrophage chemotaxis. This article reviews the possible role of PAI-1, as one of the SASP markers, and speculates the potential role of PAI-1 in adipose tissue senescence and inflammatory macrophage infiltration in obesity.