Copper-Catalyzed Aerobic Oxidative Ring Expansion of Isatins:A Facile Entry to Isoquinolino-Fused Quinazolinones

• 作者: Dahan Wang Fuhong Xiao Feng Zhang Huawen Huang Guo-Jun Deng
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Concise Reports
• 页码范围: 87-92
• 页数: 6页
• 语种: 英文
• DOI: 10.1002/cjoc.202000368

摘要

A copper-catalyzed aerobic oxidative ring expansion reaction of isatins with 1,2,3,4-tetrahydroisoquinoline for the synthesis of tetra-cyclic quinazolinones has been developed.This reaction is performed smoothly under simple conditions to give the corresponding products in moderate to good yields with good functional group tolerance.The capacity of the resultant 5H-isoquinolino[1,2-b]quina-zolin-8(6H)-one for a range of palladium-catalyzed directing C-H activation has been further demonstrated,thus giving a broader access to diverse tetracyclic quinazolinones.