Transition-metal-free synthesis of 1,4-benzoxazepines via[4+3]-cycloaddition of para-quinone methides with azaoxyallyl cations

• 作者: Shuang-Jing Zhou Xiao Cheng Chun-Xia Hu Guo-Yong Xu Wen-Jing Xiao Jun Xuan
• 来源期刊: 中国科学：化学（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: ARTICLES
• 页码范围: 61-65
• 页数: 5页
• 语种: 英文

摘要

A formal[4+3]-cycloaddition reaction of ortho-hydroxyphenyl-substituted para-quinone methides(p-QMs)with in-situ gen-erated azaoxyallyl cations is reported.The reaction occurs under very mild reaction conditions(transition-metal free,room temperature,cheap inorganic base)and provides a very efficient route to a series of biologically important 1,4-benzoxazepine derivatives in good to excellent yields.