The rs2227481 C>T Polymorphism in the IL22 Gene Promoter Significantly Reduces the Risk of Liver, Lung, and Gastric Cancer in a Han Chinese Population

• 作者: CHAI Long Long XIAO Ying Xuan MENG Ling Han WANG Huan FENG Xian Hong GU Xiu Li LI Qi Chang XIONG Qian Tao CHEN Bi Feng
• 来源期刊: 生物医学与环境科学（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 572-576,中插25-中插30
• 页数: 1页
• 语种: 英文
• DOI: 10.3967/bes2021.079

摘要

Cancer is a serious threat to public health and the economy worldwide. Statistical data from the World Health Organization (WHO) in 2018 have demonstrated that lung cancer is the most commonly diagnosed cancer (11.6％ of the total cases) and the leading cause of cancer death (18.4％of the total cancer deaths), closely followed by gastric cancer (5.7％ and 8.2％), and liver cancer (4.7％ and 8.2％)[1]. The situation is similar for these three types of cancer in the Hubei province of China[2]. Interleukin-22 (IL22), a member of the IL-10 family, is regarded as a link between inflammation and cancer. Recent studies have shown that IL22 acts as a tumor promoter and may promote carcinogenesis rather than function in antitumor immunity[3]. Interestingly, evidence of IL22 involvement in carcinogenesis manifests as dysregulation of IL22 expression in patients with many common cancers, including those of the stomach, liver, lung, stoma gut, and skin[4]. Therefore, it is hypothesized that individuals carrying certain genetic variants in the IL22 gene are vulnerable to the challenge of dysimmunity and are more susceptible to cancer. To test this hypothesis, we adopted a two-stage case-control approach to explore the potential contribution of IL22 gene promoter polymorphisms to cancer susceptibility in a Chinese Han population of Hubei province, and further elucidated the specific mechanism underlying the contribution of associated polymorphisms to cancer susceptibility.