A positive feedback regulatory loop involving the lncRNA PVT1 and HIF-1α in pancreatic cancer

• 作者: Yiping Zhu Fang Wu Weiwei Gui Nan Zhang Erik Matro Linghua Zhu Daniel Turunen Eserberg Xihua Lin
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2021,（9）
• 所属期刊栏目: Articles
• 页码范围: 676-689
• 页数: 14页
• 语种: 英文
• DOI: 10.1093/jmcb/mjab042

摘要

Extreme hypoxia is among the most prominent pathogenic features of pancreatic cancer (PC).Both the Long non-coding RNA(lncRNA) plasmacytoma variant translocation 1 (PVT1) and hypoxic inducible factor-1α (HIF-1α) are highly expressed in PC patients and play a crucial role in disease progression.Reciprocal regulation involving PVT1 and HIF-1α in PC,however,is poorly understood.Here,we report that PVT1 binds to the HIF-1α promoter and activates its transcription.In addition,we found that PVT1 could bind to HIF-1α and increases HIF-1α post-translationally.Our findings suggest that the PVT1-HIF-1α positive feedback loop is a potential therapeutic target in the treatment of PC.